Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-778-1 | CAS number: 7726-95-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference in a foreign language, and not yet available
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of Halogens on an Organism
- Author:
- Tswapo V V, VN Kupyrov, RK Gakol et al.
- Year:
- 1 975
- Bibliographic source:
- Gig Sanit 6:92-93 English summary from Chem Abstr 83:14261r
Materials and methods
- Principles of method if other than guideline:
- Rats were given bromine in drinking water. Behavioral and reflex observations, blood and blood chemistry analysis, examination of internal organs were conducted.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Bromine
- EC Number:
- 231-778-1
- EC Name:
- Bromine
- Cas Number:
- 7726-95-6
- Molecular formula:
- Br2
- IUPAC Name:
- dibromine
- Details on test material:
- Although this study cites bromine as the test article, when addded to drinking water, elemental bromine is not likely to be present. The test article, thus, would actually be hypobromous acid and other brominated oxidants formed.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: drinking water
- Duration of treatment / exposure:
- Six month exposure
- Frequency of treatment:
- Daily
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0.01 mg/kg
Basis:
nominal in water
- Remarks:
- Doses / Concentrations:
Unspecified lower doses
Basis:
nominal in water
Results and discussion
Results of examinations
- Details on results:
- Reported effects included altered behavior, decreased erythrocyte and leukocyte counts, decreased hemoglobin levels, lower cholinesterase and alkaline phosphatase activity, decreased phagocytic action of neutrophils, and increased ascorbate content of the adrenal glands. Unspecified lower doses of bromine did not significantly alter conditioned reflexes, blood indicies or internal organs.
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 0.01 mg/kg bw/day (nominal)
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In a 6 month study with rats given 0.01 mg/kg bromine in drinking water, reported effects included altered behavior, decreased erythrocyte and leukocyte counts, decreased hemoglobin levels, lower cholinesterase and alkaline phosphatase activity, decreased phagocytic action of neutrophils, and increased ascorbate content of the adrenal glands. Unspecified lower doses of bronime did not significantly alter conditioned reflexes, blood indicies or internal organs.
- Executive summary:
In a 6 month study with rats given 0.01 mg/kg bromine in drinking water, reported effects included altered behavior, decreased erythrocyte and leukocyte counts, decreased hemoglobin levels, lower cholinesterase and alkaline phosphatase activity, decreased phagocytic action of neutrophils, and increased ascorbate content of the adrenal glands. Unspecified lower doses of bronime did not significantly alter conditioned reflexes, blood indicies or internal organs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
