Registration Dossier
Registration Dossier
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EC number: 231-778-1 | CAS number: 7726-95-6
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: clinical observation
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Bromine Gassing
- Author:
- Suntych F
- Year:
- 1 970
- Bibliographic source:
- Prac Lek 5:86, 1953
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: inhalation
Test material
- Reference substance name:
- Bromine
- EC Number:
- 231-778-1
- EC Name:
- Bromine
- Cas Number:
- 7726-95-6
- Molecular formula:
- Br2
- IUPAC Name:
- dibromine
- Details on test material:
- - Name of test material (as cited in study report): Bromine
- Physical state: vapor
- Other: accidental exposure in workplace to unknown concentration
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 8
- Sex:
- Age:
- Race:
- Demographic information:
- Known diseases:
- Other: - Ethical approval:
- not applicable
- Route of exposure:
- inhalation
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- Bronchopneumonia in three victims, blepharospasm in one and chronic laryngitis in the remainder. Death occurred in one case as a result of sudden circulatory failure associated with bronchopneumonia.
- Outcome of incidence:
- One death.
Applicant's summary and conclusion
- Conclusions:
- Accidental acute occupational exposure to an unknown concentration of bromine vapor resulted in clinical signs of blepharospasm (1 of 8), and respiratory distress (resulting from bronchopneumonia in 3/8) and chronic laryngitis in the remainder. One patient died of circulatory failure in association with the bronchopneumonia.
- Executive summary:
Accidental acute occupational exposure to an unknown concentration of bromine vapor resulted in clinical signs of blepharospasm (1 of 8), and respiratory distress (resulting from bronchopneumonia in 3/8) and chronic laryngitis in the remainder. One patient died of circulatory failure in association with the bronchopneumonia.
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