Registration Dossier
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EC number: 604-580-1 | CAS number: 147256-33-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EL50 (48h) > 100 mg/L (nominal, WAF) for Daphnia magna (EU method C.2)
Key value for chemical safety assessment
Additional information
Three studies investigating the short-term toxicity of Fatty acids, C18-unsatd., dimers, mixed esters with oleic acid and trimethylolpropane (CAS No. 147256-33-5) to aquatic invertebrates are available. The key study was performed under static conditions according to GLP and EU method C.2 using Daphnia magna as test organism (Kirch, 1997). Loading rate WAFs between 1000 and 10,000 mg/L were tested. Test substance monitoring revealed concentrations of 0.6 mg/L (0 h) to ~ 0.06 mg/L (48 h) in the test solutions. No immobilised Daphnia were observed in the control and any treatment after 48 h test period. Hence, the 48h-EL50 value is determined to be > 10,000 mg/L loading rate WAF. Two supporting studies showed similar results. The first supporting study was performed under static conditions according to GLP and OECD guideline 202 using Daphnia magna as test organism (Goodband, 2012). Loading rate WAFs between 10 and 100 mg/L were tested. TOC analysis of the test substance showed no significant amounts of carbon to be present (around limit of quantification) based on the low water solubility. The 48 h-EL50 is determined to be > 100 mg/L loading rate WAF. The second supporting study was also conducted according to OECD guideline 202 using Daphnia magna as test organism; however, was not performed according to GLP (Caduff, 2012). A loading rate WAF of 100 mg/L was tested in a limit test. The 48 h-EL50 is determined to be > 100 mg/L loading rate WAF.
Based on this information acute toxicity of Fatty acids, C18-unsatd., dimers, mixed esters with oleic acid and trimethylolpropane to aquatic invertebrates is greater than 100 mg/L (nominal WAF).
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