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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Study was performed, comparable with OECD 405. However, documentation of information was very limited.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964
Report date:
1964

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine
EC Number:
229-761-9
EC Name:
N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine
Cas Number:
6711-48-4
Molecular formula:
C10H25N3
IUPAC Name:
(3-{[3-(dimethylamino)propyl]amino}propyl)dimethylamine
Test material form:
liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): bis-dimethyl aminopropylamine; 3,3'-bis (dimethylamino) dipropylamine; bis (N,N'-dimethylaminopropoyl) amine
- Other: density: 0.84 g/L

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
No data

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL
Duration of treatment / exposure:
No data
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
No data
Details on study design:
No data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Remarks on result:
other: After instillation to 0.1 mL of the substance, rabbits showed immediate signs of discomfort when eyes were dosed
Remarks:
Shortly thereafter corneas appeared to be completely opaque and lids were burned and hemorrhagic. No improvement occurred during the 7 days that eyes were examined, and by that time the lids were closed, dry and necrotic.
Irritant / corrosive response data:
Rabbits showed immediate signs of discomfort when eyes were dosed, and shortly thereafter corneas appeared to be completely opaque and lids were burned and hemorrhagic. No improvement occurred during the 7 days that eyes were examined, and by that time the lids were closed, dry and necrotic.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
After instillation to 0.1 mL of the substance, rabbits showed immediate signs of discomfort when eyes were dosed, and shortly thereafter corneas appeared to be completely opaque and lids were burned and hemorrhagic. No improvement occurred during the 7 days that eyes were examined, and by that time the lids were closed, dry and necrotic.