Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
Deviations:
not specified
GLP compliance:
yes
Type of assay:
micronucleus assay

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
406-040-9
EC Name:
-
Cas Number:
125643-61-0
Molecular formula:
C24 H40 O3 C25 H42 O3 C26 H44 O3
IUPAC Name:
C7-9-(branched)-alkyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate

Test animals

Species:
hamster, Chinese
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
No. of animals per sex per dose:
Male: 5000 mg/kg; No. of animals: 24; Sacrifice time: 16 hours
Male: 5000 mg/kg; No. of animals: 24; Sacrifice time: 24 hours
Male: 5000 mg/kg; No. of animals: 24; Sacrifice time: 48 hours
Female: 5000 mg/kg; No. of animals: 24; Sacrifice times: 16 hours
Female: 5000 mg/kg; No. of animals: 24; Sacrifice times: 24 hours
Female: 5000 mg/kg; No. of animals: 24; Sacrifice times: 48 hours

Results and discussion

Test results
Genotoxicity:
negative
Toxicity:
no effects

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative