Registration Dossier
Registration Dossier
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EC number: 406-040-9 | CAS number: 125643-61-0
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- Deviations:
- not specified
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 406-040-9
- EC Name:
- -
- Cas Number:
- 125643-61-0
- Molecular formula:
- C24 H40 O3 C25 H42 O3 C26 H44 O3
- IUPAC Name:
- C7-9-(branched)-alkyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: RAI (SPF)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- 7 days per week
- No. of animals per sex per dose:
- Male: 20 animals at 0 mg/kg bw/day
Male: 20 animals at 3 mg/kg bw/day
Male: 20 animals at 10 mg/kg bw/day
Male: 20 animals at 30 mg/kg bW/day
Male: 20 animals at 100 mg/kg bw/day
Female: 20 animals at 0 mg/kg bw/day
Female: 20 animals at 3 mg/kg bw/day
Female: 20 animals at 10 mg/kg bw/day
Female: 20 animals at 30 mg/kg bw/day
Female: 20 animals at 100 mg/kg bw/day
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 3 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Although foam cells were present in the alveoli of both sexes, this was confined to rats and lungs at a high dose and is not considered to be an effect of importance.
Applicant's summary and conclusion
- Conclusions:
- Substance not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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