Registration Dossier
Registration Dossier
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EC number: 406-040-9 | CAS number: 125643-61-0
Endpoint summary
Administrative data
Description of key information
The 90 day repeat dose oral study gives NOAEL 3 mg / kg / day.
The 28 day repeat dose oral study gives NOAEL 5 mg / kg / day.
The repeat dose dermal and inhalation were waived on grounds of low toxicity.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 3 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
Justification for classification or non-classification
All physiological effects in the 28-day repeat dose toxicity study: oral, were completely reversible.
The 90-day repeat dose toxicty study: oral, did show foam cells in the alveoli of both sexes which can represent phospholipidosis. However this was confined to rats and lungs at a high dose and is not considered to be an effect of importance.
Therefore under the conditions of these studies Evernox 1135 is not classified.
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