Reaction Mass of Cyclohexanepropanol, 2,2,6-trimethyla-propyl-, (alpha.R,1R,6S)- and Cyclohexanepropanol,2,2,6-trimethyl-a-propyl-, [1a(S*),6b]- (9CI)

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

experimental phase 24-25. Feb. 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. No significant deviation was reported. The test substance is adequately characterised, with its isomers composition. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

GLP compliance:

yes (incl. QA statement)

Remarks:

inspected on November 13 and 14, 2014 / signed on April 08, 2015

Type of method:

effusion method: by loss of weight or by trapping vaporisate

Specific details on test material used for the study:

- Storage condition of test material: The test item was stored in closed aluminium bottles at 11 - 25 °C, except of two days below 11°C (deepest temperature 10.1°C) C, away from light.

Temp.:

20 °C

Vapour pressure:

0.128 Pa

Remarks on result:

other: extrapolated from the measuring range 25-65°C

Key result

Temp.:

25 °C

Vapour pressure:

0.194 Pa

Remarks on result:

other: interpolated from the regression

The measured values for temperature and vapour pressure were evaluated as follows:

Parameter	T	P	1/T	log P
Unit	K	Pa	1/K	log Pa
Values	298.2	0.205	3.3535E-03	-0.6892
	318.2	0.818	3.1427E-03	-0.0872
	338.2	3.75	2.9568E-03	0.5741

A graph with log P (in Pa) vs. 1/T (in K) was plotted. Since the values were correlated by a linear relation, the data could be fitted by linear regression:

log P = -3177.7 / T + 9.9454

Correlation Coefficient r = -0.9980

Coefficient of Determination r² = 0.9960

Upon inspection of the cells at the end of the experiment, it was observed that the test item had not changed in appearance.

Vapour pressure results, in Pa

Temperature	25°C	45°C	65°C
mean	0.205	0.818	3.75
SD (+/-)	0.0258	0.0821	0.118
RSD	12.6%	10.0%	3.2%

(detailed measurements are available in the study report)

Conclusions:

Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).

Executive summary:

The vapour pressure of the test item was determined under GLP following OECD 104/EU A.4 guideline, effusion method (weight loss).

Determinations were conducted at 25, 45 and 65 °C. All temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (P). The graph shows a straight line with a correlation coefficient (r) of - 0.9980.

For the test item, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C:        0.128 Pa (extrapolated)

Vapour pressure at 25 °C:        0.194 Pa (interpolated, key)

Description of key information

Low volatility.

No differential volatilisation of isomers in the measuring range.

Key value for chemical safety assessment

Vapour pressure:

0.194 Pa

at the temperature of:

25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study. The result at 25°C, interpolated from experimental determinations at 25-45-65°C, is retained as key data.