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EC number: 435-680-1
CAS number: -
An acute inhalation toxicity study according to the OECD guideline 436
was performed. The only study group, consisting of 6 Wistar rats (3
males and 3 females), was exposed to the target concentration of 5 mg
test substance/L as an aerosol. The animals were exposed for 4 hours
using a nose-only exposure system, followed by a 14-day observation
period. Aerosol concentration was measured gravimetrically. The particle
size distribution of the test aerosol was determined regularly during
the exposure period. Clinical observations and bodyweights were recorded
throughout the study and at the end of the scheduled period the animals
were euthanised and subjected to a gross examination post mortem.
Gravimetric results of the test atmosphere analysis:
The mean achieved concentration in the study was 5.12 mg/L. The mass
median aerodynamic diameter (MMAD) was 3.81 μm with a geometric standard
deviation (GSD) 2.67. The quality of the test atmosphere complied with
criteria documented in the guideline.
Mortality: No animals died during the study.
Clinical observations: Only dyspnoea (3/3 m, 3/3 f) and red stating
around snout (3/3 m, 3/3 f) were recorded in the animals during and/or
shortly after the exposure. All animal recovered and no significant
clinical signs were recorded from the day following exposure until the
end of the observation period.
Bodyweight: Normal bodyweight gain was noted during the two weeks
Necropsy: No test item-related macroscopic alterations were detected.
The acute inhalation LC50 of the test substance in Wistar rats is >5.12
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