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EC number: 284-219-9
CAS number: 84812-94-2
Two experiments were performed.
In the first experiment (pre-test) the test item was tested using 4
concentrations ranging from 1000 to 1 mg/L nominal concentration.
To avoid volatilization and for safety reasons, the experiments were
performed in a closed system without aeration. In order to ensure
sufficient oxygen supply, a large headspace is provided and the mixtures
are stirred vigorously. This procedure is described in the OECD guideline
All validity criteria were met. For the estimation of the EC50 of the
positive control, the fits showed good statistical correspondence of the
data with the dose-response-equation. The positive control gave an EC50
of 8.8 mg/L (confidence interval: not determinable) first experiment
(pre-test) and 12 mg/L (confidence interval 9.9 – 15 mg/L) in the second
experiment (main test), which lie within the recommended range of 2 – 25
mg/L. The coefficient
of variation of oxygen uptake rate in control replicates was below 30%
at the end of the test. The oxygen uptake rate of the blank controls was
above 20 mg O2 per gram activated sludge in 1 hour.
Because significant inhibition was observed, an additional experiment
was performed. In the second experiment (main test) the test item was
tested using 5 concentrations ranging from 1000 to 10 mg/L nominal
concentration. At the highest concentration 1000 mg/L total inhibition
was observed. The NOEC can be stated as 32 mg/L, the EC10 as 23 mg/L and
the EC50 was determined with 130 mg/L.
All replicates showed a very good agreement.
No inconsistencies in the dose-response estimation could be observed.
Therefore, no further experiment was performed in order to discern
between inhibition of nitrificators and inhibition of total population.
No observations were made which might cause doubts concerning the
validity of the study outcome.
The result of the test can be considered valid.
The following results for the test item β-Alanine, N-coco alkyl derivs.;
water based version were determined:
3h NOEC = 32 mg/L
3h EC10 = 23 mg/L (confidence interval 17- 30 mg/L)
3h EC50 = 130 mg/L (confidence interval 100 – 160 mg/L)
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