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EC number: 413-110-2 | CAS number: 135861-56-2
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 5th March 1993 to 1st October 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Directive84/449: Method A7
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
Constituent 1
Results and discussion
Solubility in organic solvents / fat solubility
- Medium:
- standard fat
- Solubility:
- 0.004 other: g/100g fat
- Temp.:
- 37 °C
- Test substance stable:
- not determined
- Details on results:
- Solubility in fat was very low whatever parameter (temperature or stirring time) was modified and no significant differences were observed between the results.
Any other information on results incl. tables
Table 1: Fat solubility measurements
Groups |
Values mg/kg |
Means mg/kg |
Results g/1000g |
Results g/100g |
Mean g/100g |
Standard deviation |
GRA 1-1 |
1.467 |
1.197 |
9.90E-02 |
9.90E-03 |
4.49E-03 |
3.61E-03 |
GRA 1-1 |
0.927 |
|||||
GRA 1-2 |
0.686 |
0.783 |
||||
GRA 1-2 |
0.879 |
|||||
GRA 2-1 |
0.239 |
0.265 |
2.60E-02 |
2.60E-03 |
||
GRA 2-1 |
0.290 |
|||||
GRA 2-2 |
0.215 |
0.255 |
||||
GRA 2-2 |
0.294 |
|||||
GRB 1-1 |
0.228 |
0.197 |
2.45E-02 |
2.45E-03 |
||
GRB 1-1 |
0.165 |
|||||
GRB 1-2 |
0.304 |
0.294 |
||||
GRB 1-2 |
0.283 |
|||||
GRB 2-1 |
0.266 |
0.289 |
3.02E-02 |
3.02E-03 |
||
GRB 2-1 |
0.311 |
|||||
GRB 2-2 |
0.299 |
0.315 |
||||
GRB 2-2 |
0.330 |
GRA: Group A
GRB: Group B
Applicant's summary and conclusion
- Conclusions:
- Under the experimental conditions described, the fat solubility was estimated to be 0.00449 g/100 g fat at 37°C.
Solubility in fat was very low whatever parameter (temperature or stirring time) was modified and no significant differences were observed between the results. - Executive summary:
In a general physico-chemical properties study (13193), the fat solubility of the test material was determined to be 0.00449 g/100g fat, according to Method A7 of EEC Directive 984/449 and OECD Guideline 116.
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