(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

PNEC aqua (freshwater)

PNEC value:

0.003 mg/L

Assessment factor:

10

Extrapolation method:

assessment factor

PNEC freshwater (intermittent releases):

0 mg/L

Marine water

Hazard assessment conclusion:

PNEC aqua (marine water)

PNEC value:

0 mg/L

Assessment factor:

100

Extrapolation method:

assessment factor

STP

Hazard assessment conclusion:

PNEC STP

PNEC value:

100 mg/L

Assessment factor:

10

Extrapolation method:

assessment factor

Sediment (freshwater)

Hazard assessment conclusion:

PNEC sediment (freshwater)

PNEC value:

0.494 mg/kg sediment dw

Assessment factor:

10

Extrapolation method:

equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:

insufficient hazard data available (further information necessary)

Hazard for air

Air

Hazard assessment conclusion:

no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

PNEC soil

PNEC value:

10 mg/kg soil dw

Assessment factor:

100

Extrapolation method:

assessment factor

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:

PNEC oral

PNEC value:

90 300 g/kg food

Assessment factor:

90

Conclusion on classification

The EC₅₀for Daphnia and LC₅₀for fish is >0.04 mg/L and so under Directive 67/548/EC 1,3:2,4-Bis-O-(3,4-dimethylbenzylidene)-D-glucitol should be classified as R50 (Very toxic to aquatic organisms). However the water solubility of 1,3:2,4-Bis-O-(3,4-dimethylbenzylidene)-D-glucitol is 0.0476 mg/L and so results from these studies have to be considered with caution. It is considered that due to the low water solubility of the substance, a study performed using higher test concentrations would show that the substance is not classified in line with Directive 67/548/EEC because of its very low water solubility. On this basis no classification is required.

Although the substance is classified as not readily biodegradable, the aquatic BCF is <150 and the chronic NOEC for Daphnia is above the water solubility limit thus R53 (May cause long-term adverse effects in the environment) is not considered to be required. The hazard symbol ‘N’ (Dangerous for the environment) is also not required.