Registration Dossier
Registration Dossier
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EC number: 500-047-1 | CAS number: 26316-40-5 1 - 4.8 moles ethoxylated and 1 - 8.5 moles propoxylated
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
An LLNA study was conducted according to OECD 429. Female CBA/Ca mice (five/group) received 0.5%, 5%, or 50% (v/v) test substance diluted using 4:1 acetone:olive oil (AOO). Lymph node stimulation indices of greater than three (3) were measured for the 50% test group relative to AOO vehicle mice. The test substance was considered to be a sensitizer under the conditions of the test.
The skin sensitizing potential of the test item NLP#6 was investigated in a guinea pig maximisation test according to OECD 406. Male guinea pigs were treated intradermally (together with Freund's adjuvant) and epicutaneously (lowest irritating concentration) with the test item. 21 days after first administration, the test item was applied epicutaneously at the highest non-irritating concentration.
No skin reactions were observed in the animals of the test group and in the control animals after challenge. The performance of the test system was checked by a positive control study with the known skin sensitizer alpha-Hexylcinnamaldehyde in the month of the study start.
As the substance was positive in a LLNA with mice, the substance was classified as sensitising to skin.
Migrated from Short description of key information:
Sensitiser in an LLNA with mice.
Justification for classification or non-classification
The results from a LLNA do warrant classification as sensitising in the EU.
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