Registration Dossier
Registration Dossier
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EC number: 500-047-1 | CAS number: 26316-40-5 1 - 4.8 moles ethoxylated and 1 - 8.5 moles propoxylated
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2d: Test procedure in accordance with national standard methods with acceptable restrictions.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- Deviations:
- no
- Principles of method if other than guideline:
- Method: other: Federal Register, 1973, 38, 27019
- GLP compliance:
- no
Test material
- Details on test material:
- Voranol RA 800; Molecular Mass: (average Mn = 280 g/mol)
; Units of Propylene oxide, approx: 70-90%, Units of ethylene oxide: approx 10-30%
Lot #: not specified in the report
Colourless viscous Fluid
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- semiocclusive
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 24 hour(s)
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- other: all six animal
- Time point:
- other: 24 hr
- Score:
- 0.84
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 72 hrs
- Remarks on result:
- other: slight redness - no swelling observed
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- other: all six animals
- Time point:
- other: 72 hr
- Score:
- 0
- Max. score:
- 8
Any other information on results incl. tables
Slight redness but no swelling was observed after 24 hrs in all animals. Primary irritation score was 0.84 out of possible 8.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- EDA EO + PO was found very slightly irritating. The findings do not warrant classifcation according to the EU criteria.
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