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EC number: 930-690-7
CAS number: -
The eye irritation potential of shale oils, medium was examined in an
experiment according to OECD 404 and performed to GLP. Shale oils, heavy
was applied to the torso of 2 female and 1 male New Zealand white
rabbit, and held in place with a semi-occlusive dressing for 4 hours.
After the exposure, the test substance was washed off and the rabbits
were then observed for 14 days.
The mean chemosis score of the three animals at the mean of the 24, 48
and 72 hour timepoints was 2.11. Using the referred classification
(Commission Directive 2001/59/EC of August 06, 2001), Shale oil is
considered to be “irritating” to the rabbit eye on this basis. No other
scores reached the threshold for classification.
Based on the rationale for read-across, it is considered acceptable to
use this study to address the same endpoint for the heavy fraction of
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