Registration Dossier
Registration Dossier
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EC number: 215-211-5 | CAS number: 1313-82-2
Carcinogenicity
Administrative data
Description of key information
For the sodium sulfide as well as for sodium hydrogensulfide, no adequate data from carcinogenicity studies are available, and therefore, information from other substances related to sulfides is considered for evaluation of the carcinogenic hazard.
The evaluation report is attached to the technical dossier and the CSR.
Key value for chemical safety assessment
Justification for classification or non-classification
There is no conclusive evidence for any carcinogenic potential of H2S in the public domain, despite that it is well-known that H2S can elicit local effects in the respiratory tract. Upon systemic availability, sulfides are rapidly oxidised and excreted renally as sulfates. Regarding sulfur and sulfates, there is a general opinion that these compounds are essential for life and do not pose a risk for humans.
Thus, in the absence of any conclusive human or animal evidence for any carcinogenic effect, the complete lack of genotoxicity of sulfides, and given the metabolic profile and natural geogenic ubiquitous presence of sulfides in the environment, there is no need for the conduct of a carcinogenicity study, and this data requirement should therefore be waived.Additional information
An extensive literature search and evaluation programme on animal and human repeated dose toxicity data of sodium sulfide, sodium hydrogensulfide and dihydrogen sulfide has recently been conducted. However, no adequate data from carcinogenicity studies are available. Therefore, information from other substances related to sulfides is considered for evaluation of the carcinogenic hazard.
The evaluation report is attached to the technical dossier (IUCLID section 7.7) and included in the CSR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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