Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-211-5 | CAS number: 1313-82-2
Endpoint summary
Administrative data
Description of key information
No reliable studies on skin irritation, eye irritation or respiratory irritation are available for sodium sulfide. As sodium sulfide is classified for skin corrosivity and has a pH value above 11.5 no testing need to be conducted.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
General
A literature search and evaluation programme on animal and human irritation data of sodium sulfide has been conducted. All data sources were assessed by expert toxicologists for quality and reliability, as well as relevance for regulatory risk assessment under REACH. The results are attached to the technical dossier in a tabular report (IUCLID section 13).
Skin irritation
Studies on dermal irritation/corrosion with sodium sulfide are neither available nor proposed, based on scientific considerations and for reasons of animal welfare:
(i) In accordance with section 8.1, column 2, Annex VII of regulation (EC) 1907/2006, the in-vitro skin irritation study does not need to be conducted as the available information indicates that the criteria are met for classification as corrosive to the skin.
(ii) In accordance with section 8.1.1, column 2, Annex VIII of regulation (EC) 1907/2006, the in-vivo skin irritation study does not need to be conducted since the substance is classified as corrosive to the skin and furthermore, the substance is a strong base (pH≥11.5).
The classification and labelling of sodium sulfide is adequately addressed under Directive 67/548/EEC and Commission Regulation (EC) No 790/2009 (1. ATP of Regulation No 1272/2008).
Eye irritation
No studies on eye irritation with sodium sulfide are available and none are proposed, based on scientific considerations and for reasons of animal welfare. In accordance with section 8.2, column 2, Annex VII of regulation (EC) 1907/2006, the in-vitro eye irritation study does not need to be conducted since the available information indicates that the criteria are met for classification as corrosive to the skin. Similarly, in accordance with section 8.2.1, column 2, Annex VIII of regulation (EC) 1907/2006, the in-vivo eye irritation study also does not need to be conducted since the substance is classified as corrosive to the skin and the registrant undertakes to classified the substance as eye irritant. Furthermore, the substance is a strong base (pH≥11.5).
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Sodium sulfide is listed on Annex I of Directive 67/548/EEC with a classification as "Corrosive' (R34); Causes burns" and on Commission Regulation (EC) No 790/2009 (1. ATP of Regulation No 1272/2008), Annex I: List of harmonised classification and labelling of hazardous substances in Regulation No 1272/2008 as skin corrosive cat. 1b, "H314 Causes severe skin burns and eye damage".
No reliable data are available on skin irritation properties of sodium sulfide. Thus, based on the caustic alkaline nature of the compound (extreme pH), the harmonised classification of sodium sulfide according to Commission Regulation (EC) No. 790/2009: 1. ATP of CLP Regulation No 1272/2008; Annex I and Annex IV should be adopted: legal classification as skin corrosive Cat.1B (causes severe skin burns and eye damage) according to GHS and corrosive, R34: Causes Burns according to Directive 67/548/EEC.
According to Regulation No 1272/2008 (3.3.2.3) skin corrosive substances shall be considered as leading to serious damage to the eyes as well (Category 1). Sodium sulfide should therefore be classified as eye irritant Cat.1 (irreversible effects on the eye).
Furthermore, sodium sulfide has to be classified according to GHS as "corrosive to the respiratory tract". This is valid for substances and mixtures in addition to classification for skin corrosivity, if no acute inhalation test data are available and which are inhaled. This applies for sodium sulfide.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
