Zirconium dichloride oxide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

no data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Well documented, scientifically sound study according to a method similar to OECD 401 "Acute Oral Toxicity" with the following deviations: (1) The number of deaths at each dose were not reported; (2) the specific doses (mg/kg) were not provided; (3) individual clinical observations, body weights, pathology were not reported; (4) sex of the animals was not provided.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1950

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

see rationale for reliability

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Zirconium dichloride oxide

EC Number:

231-717-9

EC Name:

Zirconium dichloride oxide

Cas Number:

7699-43-6

Molecular formula:

Cl2OZr

IUPAC Name:

Dichloro(oxo)zirconium

Test material form:

solid: crystalline

Details on test material:

- Name of test material (as cited in study report): zirconium oxychloride
- Physical state: crystals

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: Adults
- Weight at study initiation: 200 - 300 g
- Diet (e.g. ad libitum): ad libitum, purina chow
- Water (e.g. ad libitum): ad libitum
- Fasting period before study: no data
- Housing: maintained in air-conditioned rooms

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 50%

Doses:

Specific doses administered were not provided

No. of animals per sex per dose:

22 rats were used (sex of the animals was not provided)

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 10 days, an initial group of animals receiving the test subsance was kept for 30 days to verify if any significant mortality occurred after the tenth day.

Statistics:

The LD50 values were obtained from 10-day mortality data by using the log-probability method.

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 3 500 other: mg/kg bw

Based on:

test mat.

Mortality:

The LD50 was calculated to be 3500 mg compound/kg (990 mg metal/kg). The time of death varied from a few hours to a few days following the exposure to the test substance. Few deaths were reported later than five days after exposure to test substance. Individual animal data were not provided.

Clinical signs:

other: Animals exposed to the test substance showed a progressive depression and decrease in activity until death occurred.

Gross pathology:

No gross pathological changes were reported in any of the animals receiving lethal doses of the test substance.

Other findings:

No physiologic changes were reported in any of the animals receiving lethal doses of the test substance.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The acute oral LD50 in rats via gavage was calculated to be 3500 mg/kg bw for zirconium dichloride oxide.