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EC number: 231-717-9
CAS number: 7699-43-6
Acute toxicity: oralOne reliable study was available which determined a LD50 of 3500 mg/kg bw in rats (Cochran et al., 1950).Acute toxicity: inhalationNo study required. In addition the substance is corrosive.Acute toxicity: dermalNo study needs to be conducted as the substance is skin corrosive.Acute toxicity: other routesOne reliable study was available for the intraperitoneal route of exposure and determined a LD50 of 400 mg/kg bw (Cochran et al., 1950).
Some animals died during the 24 hours following administration. For the
survivors, the behavior is characterized by inappetence, progressive
emaciation, prostrate animal, dull coat. At autopsy often
gastrointestinal necrosis and sometimes lung necrosis are found.
Acute oral toxicity
Cochran et al. (1950) observed an acute oral LD50 of 3500 mg compound/kg
bw for zirconium dichloride oxide in Sprague-Dawley rats. The time of
death varied from a few hours to a few days following the exposure to
the test substance. Few deaths were reported later than five days after
exposure to test substance. Individual animal data were not provided.
Animals exposed to the test substance showed a progressive depression
and decrease in activity until death occurred. No gross pathological
changes were reported in any of the animals receiving lethal doses of
the test substance. No physiological changes were reported in any of the
animals receiving lethal doses of the test substance. This study was
considered reliable with restrictions (Klimisch 2) and was selected as
key study to cover the endpoint. The results from this study are
supported by a non-reliable (Klimisch 3) study from Delongeas et al.
(1983) reporting a LD50 of 4330 mg/kg bw for mice.
Acute inhalation toxicity
An acute inhalation study does not need to be conducted as the substance
is classified as corrosive to skin (according to REACH Annex VIII
section 8.5, column 2). In addition, there is sufficient evidence
available indicating that zirconium is barely absorbed after exposure
via inhalation (see section 7.1) and is therefore of low bioavailability.
Acute toxicity: dermal
An acute dermal toxicity study does not need to be conducted as the
substance is classified as corrosive to skin (according to REACH Annex
VIII section 8.5, column 2). Furthermore the dermal route of exposure is
not the most appropriate route as exposure via inhalation is more likely
and there is no indication from the physicochemical properties of
significant absorption through the intact skin.
Acute toxicity: other routes
Cochran et al. (1950) observed an acute LD50 of 400 mg compound/kg bw in
Sprague-Dawley rats after intraperitoneal injection.
Based on the available data and according to the DSD/CLP criteria
zirconium dichloride oxide should not be classified for acute toxicity
via the oral route of exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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