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EC number: 201-766-0
CAS number: 87-69-4
The following organs were weighed at autopsy: adrenals, bladder, brain,
heart, kidneys, liver, lung, prostate, spleen, stomach, testes, and
thyroid. The histologic changes observed in the experimental groups were
similar to those seen in the control group. Mild focal pyelonephritis,
moderate congestion, mild hyperplasia of tubular epithelium, and
occasionai protein casts and hyaline droplet' degeneration were noted in
the kidneys, while livers of rabbits in ali groups exhibited
pericholangitis, bile duct proliferation, and dilatation as well as
moderate congestion. These changes are not unusual in rabbits and are
not to be attributed to the experimental feeding.
Examination of the testes revealed that the seminiferous tubules, the
interstitial cells, and spermatogenesis were normal in all groups.
Slight peritubular fibrosis and mild stromal hyalinization were observed
in each group after 150 days of feeding.
A subchronic study with 15 male rabbits for 150 days were performed. The
rabbits were maintained on a diet containing 7.7% sodium tartrate
(equivalent to 5% of tartaric acid) (isomer not specified). Examination
of the adrenals, heart, kidneys, liver, lung, bladder, brain, prostate,
stomach, spleen, testes, and thyroid were conducted at intervals during
the study and at the conclusion of the study. There was no effect on
growth, mortality, or foodi consumption, and no histopathological
changes could be attributed to sodium tartrate.
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