Registration Dossier
Registration Dossier
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EC number: 201-766-0 | CAS number: 87-69-4
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study has been assessed for the use in a category approach. According to the methodology and to the extent of available details, the study has been judged as reliable with restrictions.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Toxicology of the Eye (3rd ed)
- Author:
- Grant WM
- Year:
- 1 986
- Bibliographic source:
- Charles C. Thomas Publisher, Springfield, pag 518
Materials and methods
- Type of study / information:
- Tests on human eyes
- Endpoint addressed:
- eye irritation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (+)-tartaric acid
- EC Number:
- 201-766-0
- EC Name:
- (+)-tartaric acid
- Cas Number:
- 87-69-4
- Molecular formula:
- C4H6O6
- IUPAC Name:
- (2R,3R)-2,3-dihydroxybutanedioic acid
- Test material form:
- not specified
- Details on test material:
- No details on test material identity are available.
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- Three solution of tartaric acid at concentration 0.16 M was partially neutralized with sodium phosphate respectly to pH 3, pH 4, pH 5 and tested to human eyes.
- Exposure assessment:
- not specified
Results and discussion
- Results:
- Dilute solutions of tartaric acid has at times been employed as eye washes with the aim of counteracting the effects of alkalies in alkali burns. Tests on human eyes of 0.16 M tartaric acid partially neutralized to pH 3 with sodium phosphate caused severe stinging but no injury. When adjusted to pH 4, it caused mild to
moderate stinging, and at pH 5 caused only slight discomfort.
Applicant's summary and conclusion
- Conclusions:
- Dilute solutions of tartaric acid has at times been employed as eye washes with the aim of counteracting the effects of alkalies in alkali burns. Tests on human eyes of 0.16 M tartaric acid partially neutralized to pH 3 with sodium phosphate caused severe stinging but no injury. When adjusted to pH 4, it caused mild to
moderate stinging, and at pH 5 caused only slight discomfort. - Executive summary:
Dilute solutions of tartaric acid has at times been employed as eye washes with the aim of counteracting the effects of alkalies in alkali burns. Tests on human eyes of 0.16 M tartaric acid partially neutralized to pH 3 with sodium phosphate caused severe stinging but no injury. When adjusted to pH 4, it caused mild to moderate stinging, and at pH 5 caused only slight discomfort.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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