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EC number: 604-314-4
CAS number: 142844-00-6
Table 3 Terminal Body weights (SD) male rats(g)
Non fibrous aluminosilicate
Table 4 Terminal lung weights
Table 5 Clearance of test substance from the lung Mean
HALF TIME IN DAYS
Number of fibres
Number of WHO fibres
Number of fibres >20 microns long
Non fibrous alumina silicate glass
Half times calculated according to ECB/TM/26 counts less than 5% of
initial burden discounted.
Table 6 Clearance of Tracer particles from alveolar
region of lung
Half time of alveolar tracer clearance (95 CL) days
5 days post exposure
6 months post exposure
All clearance times significantly slower than control at p<0.001
RCF, amosite and AES and the non-fibrous
aluminosilicate glass deposited in the lung at concentrations
that overloaded lung clearance. But the effect of the non-fibrous
materials is much more extreme.
this study a standard protocol for the 90 day study was adapted by the
ECB. The EU guideline ECB/TM/16(97) rev. 1 was largely followed except
that some animals were allowed to survive for one year after exposure
for 90 days to
enable any pathology to resolve or develop. Cell
proliferation in the terminal bronchioles and in the lung parenchyma was
measured by the BrDU method.. The dose of fibres in the lung was
estimated by counting the fibres in the ashed tissue. RCF fibres
were counted by SEM and amosite by TEM Non fibrous aluminosilicate glass
content was measured using chemical analysis for the aluminium content
of the ash, The dust content of the lung associated lymph nodes was also
measured. The integrity of macrophage
clearance from the lungs was estimated by thoracic radioactivity
measurements after a brief inhaltion of tracer particles
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