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EC number: -
CAS number: 142844-00-6
Key Interpretation of the results from the repeated dose inhalation studies is limited due to particulate contamination of the fibre samples used
inhalation and oral data
can be considered. Dermal administration is not likely to produce any
repeated dose effects. Interpretation of the inhalation results is
complicated by the presence of non fibrous particulate in the samples
used for the 2 year inhalation studies, these particles are an artefact
caused by the method of preparation. The combination of fibres
and particles caused extreme pulmonary overload (reference section
18.104.22.168) ,which makes any extrapolation from the data scientifically
impossible.The sample used in the 90 day study (section 22.214.171.124) was
also heavily contaminated by particulate. Work place atmospheres do not
contain these particles.
Pulmonary fibrosis was produced at high
exposure concentrations in both rats and hamsters. The appropriate
classification for this material would be carcinogen category 3 under
DSD and 2 under CLP. The
pulmonary overload that led to more stringent classification under the
DSD means that there is no reason from animal experimental data to
classify for repeated toxicity
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