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EC number: 604-314-4
CAS number: 142844-00-6
chemical substances from which this material is made are not themselves
toxic. Any toxicity associated with this substance will be related to
its fibrous morphology and not its chemical composition, which is
relevant only to its biopersistence. Under normal handling and use this
substance may produce fibrous dust capable of becoming airborne and then
inhaled. The response to fibres in lung tissue is predominantly a
function of fibre size and the quantity of fibres (dose). Fibres clear
from the lung through breakage and dissolution, which are functions of
As with other vitreous fibres this material
can cause acute mechanical irritation of the skin and eyes.
DNEL cited in the long term inhalation exposure section above is based
on the chronic multi-dose rat carcinogenicity study reported by Mast et
al (Inhalation Toxicology, 1995, 7(4), 469-502) which
demonstrates a NOAEL for lung cancer of 162 f/ml and leads to the
calculated endpoint-specific DNEL of 2.17 f/ml.
have recommended an OEL for RCF of 0.3 f/ml based on measured lung
function in exposed workers. Assuming 45 years exposure, the average
cumulative exposures of 147.9 (all workers in the high exposure group)
and 184.8 fmo/ml (workers 60+ years of age in the high exposure group)
- equivalent to average fibre concentrations of 0.27 and 0.34 f/ml -
were considered as no observed adverse effect levels for lung function
and SCOEL therefore proposed an OEL of 0.3 f/ml. This is considerably
lower than the calculated DNEL value of 2.17f/ml.
This substance is restricted to professional use typically in industrial
settings and exposure of the general population therefore does not occur.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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