tris (4-nonylphenol, branch) phosphorous acid ester

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2001

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

4-(2-methyloctyl)phenyl bis(4-nonylphenyl) phosphite

EC Number:

701-028-2

Cas Number:

26523-78-4

Molecular formula:

C45H69O3P

IUPAC Name:

4-(2-methyloctyl)phenyl bis(4-nonylphenyl) phosphite

Constituent 2

Reference substance name:

Nonylphenol

EC Number:

246-672-0

EC Name:

Nonylphenol

Cas Number:

25154-52-3

IUPAC Name:

2-nonylphenol

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

New Zealand White

Test system

Type of coverage:

semiocclusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

A dose of 0.5 ml liquid test substance was applied to small area (approximately 6 cm2) of non abraded skin of 3 rabbits. Each application area was covered with a gauze patch, held in place by a non irritating tape, for an exposure period of 4 hours.

Duration of treatment / exposure:

4 hour(s)

Number of animals:

3 (1 male and 2 female)

Details on study design:

Erythema and edema scores were determined for each of three rabbits at 60 min, 24, 48 and 72 hours after patch removal (at minimum).

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 24, 48, 72 hrs

Score:

0

Results 2

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: 60 minutes

Score:

1

Max. score:

1

Reversibility:

fully reversible within: 24 hours

Irritant / corrosive response data:

Very slight erythema was observed in all rabbits following the 4-hour exposure. By the 24-hour observation point, the irritation was reversed, with no sign of erythema present at the 24-, 48- and 72-hour observations for all three rabbits. No edema was observed at any of the observation points. Based upon the Draize scale for scoring skin reaction, the test substance is considered a very slight irritant.

Any other information on results incl. tables

All of the animals exhibited a gain in body weight during the study.

No overt sign of toxicity was evident in any of the animals during the course of the study.

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated informationCriteria used for interpretation of results: EU

Conclusions:

Classification: not irritating.

Executive summary:

Very slight erythema was observed in all rabbits following the 4-hour exposure. By the 24-hour observation point, the irritation was reversed, with no sign of erythema present at the 24-, 48- and 72-hour observations for all three rabbits. No edema was observed at any of the observation points. Based upon the Draize scale for scoring skin reaction, the test substance is considered a very slight irritant.