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EC number: 701-028-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The report was scientifically acceptable.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
- Reference Type:
- publication
- Title:
- No information
- Author:
- Miller, L.C., Tainter, M.L.
- Year:
- 1 944
- Bibliographic source:
- Proc. Soc. Exptl. Biol. And Med., 57, 261
Materials and methods
Test guideline
- Deviations:
- not specified
- Principles of method if other than guideline:
- Method: other: see below
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-(2-methyloctyl)phenyl bis(4-nonylphenyl) phosphite
- EC Number:
- 701-028-2
- Cas Number:
- 26523-78-4
- Molecular formula:
- C45H69O3P
- IUPAC Name:
- 4-(2-methyloctyl)phenyl bis(4-nonylphenyl) phosphite
- Reference substance name:
- Nonylphenol
- EC Number:
- 246-672-0
- EC Name:
- Nonylphenol
- Cas Number:
- 25154-52-3
- IUPAC Name:
- 2-nonylphenol
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Diet: ad libitum - Water: ad libitum
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- cotton seed oil
- Details on oral exposure:
- Fifty young adult albino rats (5 males and 5 females/group) were fasted for 18 +/- 2 hours and given 5 graded doses (8.19 to 32.72 grams/kg) of TNPP. The sample was prepared as 50% solution in cottonseed oil and doses were administered by stomach tube.
- Doses:
- 8.19 - 11.32 - 16.38 - 22.62 - 32.72 g/kg bw.
- No. of animals per sex per dose:
- 50
- Control animals:
- other: needed for data submission
- Details on study design:
- - Duration of observation period following administration: 14 days- Necropsy of survivors performed: yes. Rats that died as well as survivors sacrificed at the end of the experiment were examined for evidence of gross pathology.
- Statistics:
- The LD50 was computed according to the method of Miller and Tainter.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 16 200 - 21 800 mg/kg bw
- Mortality:
- Mortality resulted at scattered intervals over the first five days.
- Clinical signs:
- other: All rats showed evidence of abdominal pain and catharsis after dosage. Higher doses resulted in urinary incontinence and prostration.
- Gross pathology:
- Gross pathological findings included hemorrhagic lesions in the gastric mucosa and/or duodenum in a few rats that died and hemorrhagic lungs.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated informationCriteria used for interpretation of results: expert judgment
- Conclusions:
- LD50 calculated to be 19500 +/- 3300 mg/kg. These
- Executive summary:
LD50 calculated to be 19500 +/- 3300 mg/kg.
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