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Administrative data

Description of key information

Very low acute toxicity with oral LD50 of 19.500 mg/kg and no acute effects observed dermally at a dose of 2000 mg/kg.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
19 500 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
mg/kg bw

Additional information

No human data is available. In animals, TNPP has a very low acute toxicity by the oral route, with a LD50value of about 19.5 +/- 3.3 gram/kg bw for the rat. Hemorrhagic lesions in the gastro-intestinal tract and the lungs are seen in some animals, following the administration of a lethal dose. This value was used for the risk assessment. The other studies couldn’t be used in the risk assessment due to shortcomings or unavailable study reports. Furthermore a LD50could not be derived from these studies as no mortality was observed at doses up to the highest doses tested (about 10 g/kg). Nevertheless, these results are in accordance with the value of 19.5 g/kg bw derived from the study from Naugatuck (1957).

The acute toxicity of TNPP by the dermal route seems to be very low too, with a LD50greater than 2000 mg/kg in rabbits. No data is available on the acute inhalation toxicity, although the non-corrosive and non-irritant nature of TNPP (see section on skin irritation) may suggest that toxicity would not be enhanced following exposure by this route.


By intraperitoneal route, the LD50was found to be > 1000 mg/kg in rats.

Justification for classification or non-classification

According to the criteria of the European Union, this chemical does not need to be classified on the basis of its acute toxicity.