Registration Dossier
Registration Dossier
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EC number: 200-861-4 | CAS number: 75-33-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US DoT guideline no. 49 CFR 173.240
- GLP compliance:
- no
Test material
- Reference substance name:
- Propane-2-thiol
- EC Number:
- 200-861-4
- EC Name:
- Propane-2-thiol
- Cas Number:
- 75-33-2
- Molecular formula:
- C3H8S
- IUPAC Name:
- propane-2-thiol
- Details on test material:
- No detail available
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- No detail available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- up to 72 hours
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- When exposures were terminated, moderate erythema (score 2) was present at all of the treated sites, this dissipated completely overnight. No other signs of skin irritation were discernible.
- Other effects:
- Initial skin contact evoked a mild pain reaction
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
As prescribed in 49 CFR 173.240, one -half ml of undiluted propane-2 -thiol was applied to the intact skin site under standard gauze patches of six albino rabbits. The entire fur-clipped trunk of each animal was then covered with an impervious sleeve for a skin-contact period of 4 hours and then observed during 3 days. When exposures were terminated, moderate erythema (score 2) was present at all of the treated sites, this dissipated completely overnight. No other signs of skin irritation were discernible. Propane-2 -thiol is almost slightly irritating to skin.
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