Propane-2-thiol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Undiluted propane-2-thiol was administered by stomach tube to 2 groups of 6 rats. Surviving animals were observed for 7 days

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propane-2-thiol

EC Number:

200-861-4

EC Name:

Propane-2-thiol

Cas Number:

75-33-2

Molecular formula:

C3H8S

IUPAC Name:

propane-2-thiol

Test material form:

liquid

Details on test material:

No details available

Test animals

Species:

rat

Strain:

other: WBS/W

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 200 g

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

2000 and 5000 mg/kg

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes

Statistics:

Not appropriate

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD50

Effect level:

> 2 000 - < 5 000 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

male

Dose descriptor:

approximate LD50

Effect level:

3 730 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Calculated with the standard probit method

Mortality:

0/6 at 2000 mg/kg.
6/6 at 5000 mg/kg (time for death (h): 3, >4, >4, >4, 20, 96)

Clinical signs:

other: Muscular hypothonia, motor ataxia, loss of righting reflex, recovery of righting reflex.

Gross pathology:

Findings were not significant

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

The LD50 was between 2000 and 5000 mg/kg bw.

Executive summary:

In a pre-guideline study, male WBS/W rats were dosed with iso-propyl mercaptan at doses of 2000 and 5000 mg/kg bw and followed for 7 days. Mortality was 0 and 5 of the 6 animals per group, respectively.  Signs included hypotonia, ataxia, loss of righting reflex and body weight loss. Recovery was complete in 4 days. The LD₅₀ was between 2000 and 5000 mg/kg bw and approximately 3730 mg/kg bw when calculated with the standard probit method .