Propane-2-thiol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Undiluted propane-2-thiol was administered dermally to one group of 6 rats. Surviving animals were observed for 7 days

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Propane-2-thiol

EC Number:

200-861-4

EC Name:

Propane-2-thiol

Cas Number:

75-33-2

Molecular formula:

C3H8S

IUPAC Name:

propane-2-thiol

Test material form:

liquid

Details on test material:

No details available

Test animals

Species:

rat

Strain:

other: WBS/W

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 210 g

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.46 ml/kg

Duration of exposure:

24 hours

Doses:

2000 mg/kg

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights

Statistics:

Not appropriate

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD0

Effect level:

> 2 000 mg/kg bw

Mortality:

None

Clinical signs:

other: No toxic symptoms were induced. Initial skin contact evoked a mild pain reaction.

Gross pathology:

Not reported

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Executive summary:

In a pre-guideline study, each of six rats (male WBS/W) was treated dermally with 2000 mg/kg bw (2.46 ml/kg bw) of iso-propyl mercaptan. Doses were applied under an impervious sleeve which was pre-fitted upon the fur-clipped trunk of each rat. The sleeves were removed 24 hours later and the animals were then observed for seven days. Initial vocalization and weight losses lasting up to 4 days were observed. The LD₀ was > 2000 mg/kg bw.