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EC number: 208-807-1
CAS number: 542-28-9
Oral: The acute oral LD50 was determined to be > 2000 mg/kg bw in rats. Dermal: The acute dermal LD50 was determined to be > 5000 mg/kg bw in rats.
an acute oral toxicity study (BASF SE, 1989), a group of young
adult 5 male and
female , fasted Wistar rats were
given a single oral dose of Delta-Valerolactone
in water at a
dose of 2000 mg/kg bw (limit test) and
observed for 14 days. No
clinical signs, mortality or necropsy findings were noted and no
influence on body weight was reported.
LD50Males = > 2000 mg/kg bw
Females = > 2000 mg/kg bw
Combined = > 2000 mg/kg bw
of NO NOTICEABLE toxicity based
on the LD50in male and female rats.
In accordance with column 2 of REACH Annex
VIII, the test acute toxicity after inhalation (required in section 8.5)
does not need to be conducted as acute toxicity studies for oral and
dermal application are available.
an acute dermal toxicity study (Bioassay, 2012), a group of young adult
5 male and female Wistar rats were dermally exposed to
Delta-Valerolactone (100% purity) for 24 hours to 10% of body surface
area at a dose of 5000 mg/kg bw (limit test). Animals then were
observed for 14 days. There were no treatment related clinical signs,
mortality, necropsy findings or changes in body weight.
LD50Males = > 5000 mg/kg bw
= > 5000 mg/kg bw
Combined = > 5000 mg/kg bw
is of NO NOTICEABLE toxicity based on the LD50 values in male and
Classification for acute toxicity is
not warranted according to the criteria of EU Directive 67/548/EEC and
EU Classification, Labelling and Packaging of Substances and Mixtures
(CLP) Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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