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EC number: 208-807-1
CAS number: 542-28-9
No death occured during the study.
No symptoms of local toxicity at the ears of
the animals and no systemic findings were observed during the study
The body weight of the animals, recorded
prior to the first application and prior to treatment with 3HTdR, was
within the range commonly recorded for animals of this strain and age.
Lymph nodes weights and cell count
The measured lymph node weights and –cell
counts of all animals treated were recorded after sacrifice. A
statistically significant or biologically relevant increase in lymph
node weights or cell counts was not observed in any of the test item
treated groups in comparison to the vehicle control group. For BALB/c
mice, a cutoff-value for the lymph node cell count index of 1.55 was
reported for a positive response. The indices determined for the lymph
node cell count did not exceed this threshold.
The measured ear weights of all animals
treated were recorded after sacrifice. A statistically significant or
biologically relevant increase in ear weights was not observed in any
treated group in comparison to the vehicle control group. For BALB/c
mice, a threshold for the ear weight index of 1.1 was reported for a
positive response. None of the indices determined for the test item
treated groups exceeded this threshold.
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