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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 28 October 1991 to 3 April 1992
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: According to the EEC Method A6 and it is GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl 2-cyclohexylpropionate
EC Number:
412-280-5
EC Name:
Ethyl 2-cyclohexylpropionate
Cas Number:
2511-00-4
Molecular formula:
C11H20O2
IUPAC Name:
ethyl 2-cyclohexylpropanoate
Details on test material:
- Physical state: clear, colourless liquid
- Storage condition of test material: Dark at 4ºC

Results and discussion

Water solubility
Water solubility:
0.087 g/L
Temp.:
20 °C
pH:
5.18
Details on results:
Calibration data are given in Table 7, providing a slope function of 1794.2, an intercept of -2131.2 and a regression of 0.99898 showing the calibration curve to be linear.
Analytical data are given in Table 8 showing integrated peak areas ranging between 68140 and 83398 and concentrations of 0.078330-0.095337 (mean = 0.086696) g/L and a pH range of 5.18 to 7.18.
Typical chromatograms are shown in Figure 1 and 2.
No peak at the retention time of the test substance was found in the chromatograms of the blank test solutions, showing that the analytical method was free from interferences.

Any other information on results incl. tables

Table 7

Calibration data: water solubility

Test substance concentratio (µg/ml) Integrated peak area
101,11 184029, 180230
80,888 144602, 140484, 141092, 140514
60,666 105368,1036
40,444 71786, 71167
20,222 35404, 34891
Regression  0,99898
Slope  1794,2
Intercept -2131,2

Table 8

Analytical data: water solubility

Test sample Integrated peak area Water solubility (g/l) Mean water solubility for each test (g/l) Overall mean water solubility (g/l) pH
1A 83398 0,095337 0,086834   6,46
1B 68140 0,07833   6,33
2A 73017 0,083766 0,087022 0,086696 6,23
2B 78859 0,090278 7,18
3A 74532 0,085455 0,086233   6,08
3B 75927 0,08701   5,18

pH of the blank samples: blank 1 (6.08), blank 2 (6.43) and blank 3 (6.13).

b

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water water solubility of the test substance has been determined as 0.0867 g/L at 20ºC.
Executive summary:

A study was performed to determine the water solubility of the test substance. The methods followed was EEC method A6. The water water solubility of the test substance has been determined as 0.0867 g/L at 20ºC.