Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 28 October 1991 to 3 April 1992
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: According to the EEC Method A8 and it is GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EEC Method A8
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl 2-cyclohexylpropionate
EC Number:
412-280-5
EC Name:
Ethyl 2-cyclohexylpropionate
Cas Number:
2511-00-4
Molecular formula:
C11H20O2
IUPAC Name:
ethyl 2-cyclohexylpropanoate
Details on test material:
- Physical state: clear, colourless liquid
- Storage condition of test material: Dark at 4ºC

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
4.03
Temp.:
25 °C
Details on results:
Concentration of test substance based on mass of test substance used was 1504.1µg/ml.
Test substance was not detected in either the aqueous or organic blank solutions.

Any other information on results incl. tables

Table 17
Analytical data: concentration of the test substance in octanol stock solution
Dilution Integrated peak area Analysed concentration in stock octanol solution (µg/ml) Nominal concentration in stock octanol solution (µg/ml) Concentration found expressed as percent of nominal
16,667 95576 1511,2 1504,1 100,5
16,667 94858 1499,9 1504,1 99,7
Table 18
Calculation of partition coefficient
Test Concentrations of test substance in organic phase (µg/ml) Concentration of test substance in aqueous phase (µg/ml) P Mean P for each test Mean P for all determination Log P
1A 1484,9 0,12768 11630 10821 10829 4,07
1B 1469,7 0,1468 10012 4
2A 1469,3 0,15074 9747,2 11293 3,99
2B 1405,9 0,1095 12839 4,11
3A 1493,9 0,11614 12863 10374 4,11
3B 1445,9 0,18339 7884,3 3,9
Table 19
Calculation of partition coefficient mass balance
Test Test substance concentration in octanol stock solution (µg/ml) Volume of stock used (ml) Test substance used in test (µg) Content organic phase (µg) Content aqueous phase (µg) Total µg found % recovery
1A 1504,1 10 15041 14849 12,768 14862 98,8
1B 1504,1 10 15041 14697 14,68 14712 97,8
2A 1504,1 20 30082 29386 15,074 29401 97,7
2B 1504,1 20 30082 28118 10,95 28129 93,5
3A 1504,1 40 60164 59756 11,614 59768 99,3
3B 1504,1 40 60164 57836 18,339 57854 96,2

Applicant's summary and conclusion

Conclusions:
The partition coeficient (n-octanol/water) of the test substance has been determined as Log P=4.03 at 25ºC.
Executive summary:

A study was performed to determine some physico-chemical properties of the test substance. The method followed was EEC method A8. The partition coeficient (n-octanol/water) of the test substance has been determined as Log P=4.03 at 25ºC.