Registration Dossier
Registration Dossier
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EC number: 692-448-4 | CAS number: 170621-28-0
Endpoint summary
Administrative data
Description of key information
Bioaccumulation is of no concern for the assessed substance.
Additional information
No data are available for bioaccumulation of aluminium magnesium vanadium oxide (CAS 170621-28-0). However, using the transformation/dissolution test for this substance information is provided on the release of bioavailable species of vanadium, aluminium and magnesium in the aquatic and terrestrial environment under different environmental conditions. With regard to this information, it is possible to address bioaccumulation of the substance by using a read-across towards the individual metals. Available experimental and field data on vanadium, aluminium and magnesium were used for a weight of evidence. As an essential metal, magnesium homeostasis regulates its uptake and organisms will keep their intracellular levels relatively constant across aquatic and terrestrial species. In consequence, secondary poising of magnesium is not considered relevant. Metals that are biologically essential are actively regulated in organisms (homeostasis). Non- essential metals are also actively regulated to some extent and therefore also for non-essential metals, an inverse relationship between the metal concentration and the external concentration may be observed (McGeer et al., 2003). This may explain the observed inverse relationship between BCF/BAF values and exposure concentrations of vanadium and aluminium, although the essential status of vanadium is still under discussion The available data on vanadium and aluminium suggest that both vanadium and aluminium do not biomagnify. A trophic transfer of vanadium and aluminium into aquatic/terrestrial environments is generally not a concern because bioaccumulation of vanadium and aluminium is low, whereas BCF/BAF values of vanadium is, in general less than 100 and availability of aluminium is limited by its transformation and precipitation under environmental conditions.
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