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EC number: 413-110-2
CAS number: 135861-56-2
No effects of skin corrosion and irritation have been observed.No adverse effects on eye damage or irritation have been observed.
Two "in-vivo" studies are available for each endpoint skin irritation
and eye irritation.
The two studies for skin irritation/corrsosion were performed according
EU Test Method B4 and/or OECD Guideline 404. The animals tested where
rabbits (New Zealand White, and New Zealand hybrid albino) and were
exposed for 4 hours to the substance. Erythema and edema were recorded
after 24, 48 and 72 hours after exposure of 500 mg in one of the tests,
and after 48 days after exposure of 46 mg in the other test.
Exposure to 500 mg gave a mean score of 0 in each case. Exposure to 46
mg gave erythema score max. 2, but the effects were fully reversible
after 3 days.
The results are considered valid for classification and labelling and
The two studies for eye irritation were performed according EU Test
Method B5 and/or OECD Guideline 405. The animals tested where rabbits
(New Zealand White, and New Zealand hybrid albino) treated with 20 mg of
substance in one of the tests and with 41 mg in the other test. There
were observed a few effects which were fully reversible after 3 days
(for test with 41 mg) and after 7 days (for test with 20 mg).
The available experimental test data are
reliable and suitable for classification purposes under Regulation
1272/2008. The values obtained have been compared to criteria set up in
the Annex I of the Regulation (section 3.2 for skin irritation and
section 3.3. for eye irritation). As a result the substance is not
considered to be classified as skin irritant under Regulation (EC) No.
As a result the substance is not considered
to be classified as eye irritant under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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