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EC number: 413-110-2
CAS number: 135861-56-2
Acute oral toxicity: LD50 > 5000 mg/kg bw, OECD Guideline 401Acute dermal toxicity: LD50 > 2000 mg/kg bw, OECD Guideline 402
This substance has been investigated in two
acute oral toxicity studies and two acute dermal studies. All studies
consistently show absence of mortality and target organ toxicity. All
studies were performed according to GLP and OECD guidelines.
For acute oral toxicity, the two studies
available were performed with doses of up to 5000 mg/kg bw studied with
male and female rats of different strains (Albino rats and Crl CDBR).
The test animals were feeded with the substance in oral gavage. No
mortality and no treatment-related clinical signs were recorded in any
of the two studies. As a conclusion, acute oral toxicity is therefore
For acute dermal toxicity, the two studies
available were performed with rats (Sprague Dawley). In both studies,
the substance was appliead in a semi-occlusive coverage with vehicles
liquid paraffine and arachis oil respectively. The substance applied was
2000 mg/kg and after the observation period of 24h there was no
mortality, no clinical signs and no effect on body weight gain. Any
dermal effects were observed during the treatment or after. As a
conclusion, acute dermal toxicity is therefore considered low.
The available experimental test data are
reliable and suitable for classification purposes under Regulation
1272/2008. The values obtained have been compared to the limit values as
stated in the Annex I of the Regulation (table 3.1.1.). As a result the
substance is not considered to be classified for acute toxicity under
Regulation (EC) No. 1272/2008.
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