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EC number: 413-110-2
CAS number: 135861-56-2
No non-threshold effects for this substance were identified. The
substance is considered that will be poorly taken up by the body because
of its overall low solubility. The substance does not cause local
effects. It also does not cause acute effects. The starting point for
DNEL calculations is the NOAEL (oral route - rat) from a 90-day study =
406.4 mg/kg bw/day. Following the Practical Guide 14 and the ECHA
Guidance R.8, the NOAEL oral is corrected to a NOAEC.
Correction of NOAELs for Workers
Factor for standard respiratory volume rat
Factor for absorption rat oral/ human inhalation
Factor for standard respiratory volume man and 8-h exposure
406.4 mg/kg/day (rat chronic study)
6.7 m3(8h) / 10 m3(8h)
358.27 mg/ m3
Correction of NOAELs for the general population
176.7 mg/ m3
Assumption for NOAEC: 50% absorbed orally in rats, 100% absorbed after
inhalation by man
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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