Registration Dossier
Registration Dossier
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EC number: 203-581-0 | CAS number: 108-42-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Method and results rudimentarily reported
Data source
Reference
- Reference Type:
- publication
- Title:
- The metabolism of the monochloronitrobenzenes in the Rabbit
- Author:
- Bray HG, James SP, Thorpe WV
- Year:
- 1 956
- Bibliographic source:
- Biochem J 64, 38-44 (1956)
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Rabbits were dosed with 100 mg m-chloroaniline/kg bw and the metabolites determined in the urine.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Reference substance name:
- m-chloroaniline
- IUPAC Name:
- m-chloroaniline
- Test material form:
- other: liquid
- Details on test material:
- no data
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- pobably single application
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg bw
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- Metabolites of monochlorobenzene derivatives were analyzed in the urine of rabbits. for most purposes urines were collected each 24 hours, until metabolites were no longer excreted (usually 48 hrs.).
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- After dosage with m-chloroaniline, the metabolites 2-amino-4-chlorophenol and 4-amino-2-chlorophenol was detected in the urine hydrolyzed with sulfuric acid.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
- Executive summary:
Rabbits were dosed with 100 mg m-chloroaniline/kg bw and the metabolites determined in the urine. After dosage with m-chloroaniline, the metabolites 2-amino-4-chlorophenol and 4-amino-2-chlorophenol was detected in the urine hydrolyzed with sulfuric acid.
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