3-chloroaniline

Epidemiological data

Administrative data

Endpoint:

epidemiological data

Type of information:

other: epidemiological data

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

publication

Title:

Erythrocytic inclusion bodies in the blood of chemical workers

Author:

Hughes JP, Treon JF

Year:

1954

Bibliographic source:

Arch Ind Hyg Occup Med 10, 192-202 (1954)

Materials and methods

Study type:

case control study (retrospective)

Endpoint addressed:

repeated dose toxicity: dermal

Principles of method if other than guideline:

36 male workmen occupied in the 'Aniline building' of a chemical plant were questioned in an especial thourough way as to the occurence of cyanosis, weakness, and dizziness and of symptoms referable to skin and respiratory systems. The analysis of air samples obtained in this plant revealed monomethylaniline, aniline and m-chloroaniline (0.13 and 0.29 ppm) measured on different locations.

Test material

Test material information

Constituent 1

Reference substance name:

3-chloroaniline

EC Number:

203-581-0

EC Name:

3-chloroaniline

Cas Number:

108-42-9

Molecular formula:

C6H6ClN

IUPAC Name:

3-chloroaniline

Test material form:

other: liquid

Details on test material:

no data

Method

Details on study design:

36 male workmen occupied in the 'Aniline building' of a chemical plant were questioned in an especial thourough way as to the occurence of cyanosis, weakness, and dizziness and of symptoms referable to skin and respiratory systems. The analysis of air samples obtained in this plant revealed monomethylaniline, aniline and m-chloroaniline (0.13 and 0.29 ppm) measured on different locations. The mean exposure period was 41.2 month. The mean age of the group of 36 was 28.2 years.

Exposure assessment:

measured

Results and discussion

Results:

Nine of the 36 workers gave a history of 'blue lip', i.e. methemoglobinemia, at least one during work. The clinical investigation and routine blood and urine diagnosis did not revealed no significant abnormalities. Of the 36 workmen, 28 had 1% or less of Heinz bodies in red blood cells, in no case was there more than 4%.

Confounding factors:

Aniline and monomethylaniline

Applicant's summary and conclusion

Executive summary:

36 male workmen occupied in the 'Aniline building' of a chemical plant were questioned in an especial thourough way as to the occurence of cyanosis, weakness, and dizziness and of symptoms referable to skin and respiratory systems. The analysis of air samples obtained in this plant revealed monomethylaniline, aniline and m-chloroaniline (0.13 and 0.29 ppm) measured on different locations.

Nine of the 36 workers gave a history of 'blue lip', i.e. methemoglobinemia, at least one during work. The clinical investigation and routine blood and urine diagnosis did not revealed no significant abnormalities. Of the 36 workmen, 28 had 1% or less of Heinz bodies in red blood cells, in no case was there more than 4%.