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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: OECD guideline study-GLP compliance

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Method B4 of 92/69/EEC and OECD 404
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
425-220-8
EC Name:
-
Cas Number:
5945-33-5
Molecular formula:
C39H34O8P2
IUPAC Name:
4-(2-{4-[(diphenoxyphosphoryl)oxy]phenyl}propan-2-yl)phenyl diphenyl phosphate; 4-{2-[4-({[4-(2-{4-[(diphenoxyphosphoryl)oxy]phenyl}propan-2-yl)phenoxy](phenoxy)phosphoryl}oxy)phenyl]propan-2-yl}phenyl diphenyl phosphate

Test animals

Species:
other: Rabbit (New Zealand White)

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
other: None
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
4 hours
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
other: overall at 24h, 48h and 72h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Remarks:
(mean score 2)
Time point:
other: overall at 24h, 48h and 72h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Remarks:
(mean score 3)
Time point:
other: overall at 24h, 48h and 72h
Score:
0
Irritation parameter:
erythema score
Score:
0
Remarks on result:
other: Max duration: 0 d; Max value at end of observation period: 0 (Related to all animals)
Irritation parameter:
edema score
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
other: overall at 24h, 48h and 72h
Score:
0
Irritation parameter:
edema score
Basis:
animal #2
Remarks:
(mean value 2)
Time point:
other: overall at 24h, 48h and 72h
Score:
0
Irritation parameter:
edema score
Basis:
animal #3
Remarks:
(mean value 3)
Time point:
other: overall at 24h, 48h and 72h
Score:
0
Irritation parameter:
edema score
Score:
0
Remarks on result:
other: Max duration: 0 d; Max value at end of observation period: 0 (Related to all animals)
Other effects:
None

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information