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EC number: 425-220-8
CAS number: 5945-33-5
The substance (1-methylethylidene)di-4,1-phenylenetetraphenyl
diphosphate is a mono constituent substance. Extensive data on the
toxicokinetics of (1-methylethylidene)di-4,1-phenylenetetraphenyl
diphosphate is not available. Only limited data has been provided by
ECHA via an inquiry result. No human data is available and the
toxicokinetic analysis is based on data from in vivo animal models and
in vitro cell culture models.
The substance is a mono-constituent with one component (and three
impurities).It is a liquid with a molecular weight of 692.64 g/mol.
The substance high log octanol/water partition coefficient value log P
≥ 6 and water solubility of 0.415mg/mL pH 5.7 at 20.0°C. The in vivo
studies indicated an acute oral LD50 of >2,000 mg/kg and an acute dermal
LD50 of >2,000 mg/kg. The sub-chronic oral in vivo study indicated an
oral NO(A)EL of 1,000 mg/kg. In vivo skin irritation studies in rabbits
and skin sensitisation studies in guinea pigs revealed that the
substance is not irritating or sensitising. In vivo eye irritation
studies in rabbits indicated the substance was not irritating.In vitro
mutagenicity studies in bacteria and mammalian cells with and without
metabolic activation were negative.
The available information did not suggest that the substance is expected
to be absorbed via the skin or gastro-intestinal tract. The substance
has no specific organ toxicity and is not expected to accumulate. There
is no evidence of metabolic activation. There is no evidence to indicate
the route of excretion of the substance. The substance is expected to be
excreted in the faeces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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