Registration Dossier
Registration Dossier
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EC number: 425-220-8 | CAS number: 5945-33-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The substance (1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate is a mono constituent substance. Extensive data on the toxicokinetics of (1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate is not available. Only limited data has been provided by ECHA via an inquiry result. No human data is available and the toxicokinetic analysis is based on data from in vivo animal models and in vitro cell culture models.
Overview
The substance is a mono-constituent with one component (and three impurities).It is a liquid with a molecular weight of 692.64 g/mol. The substance high log octanol/water partition coefficient value log P ≥ 6 and water solubility of 0.415mg/mL pH 5.7 at 20.0°C. The in vivo studies indicated an acute oral LD50 of >2,000 mg/kg and an acute dermal LD50 of >2,000 mg/kg. The sub-chronic oral in vivo study indicated an oral NO(A)EL of 1,000 mg/kg. In vivo skin irritation studies in rabbits and skin sensitisation studies in guinea pigs revealed that the substance is not irritating or sensitising. In vivo eye irritation studies in rabbits indicated the substance was not irritating.In vitro mutagenicity studies in bacteria and mammalian cells with and without metabolic activation were negative.
The available information did not suggest that the substance is expected to be absorbed via the skin or gastro-intestinal tract. The substance has no specific organ toxicity and is not expected to accumulate. There is no evidence of metabolic activation. There is no evidence to indicate the route of excretion of the substance. The substance is expected to be excreted in the faeces.
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