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EC number: 470-080-3
CAS number: -
Table 1: Number of revertants in the a.
standard plate test and b. preincubation test after treatment with
control or test substance in the various tester strains.
16 ± 1
16 ± 2
16 ± 2 (177 µg)
17 ± 1 (177 µg)
114 ± 11
123 ± 20
117 ± 9 (56 µg)
144 ± 19 (177 µg)
16 ± 3
17 ± 3
19 ± 2 (1750 µg)
15 ± 2 (557 µg)
111 ± 7
111 ± 8
115 ± 6 (177 µg)
121 ± 9 (56 µg)
In a GLP conform Ames test according to OECD
guideline 471, the substance 1-((2-Butyloctyloxymethyl)-2-(3,4-dihydro-isoquinolinium-2-yl)ethyl)sulfate
(purity: 93.0 weight-%) was tested for its mutagenic potential based on
the ability to induce point mutations in selected loci of several
bacterial strains, i.e. Salmonella typhimurium TA 1535, TA 100, TA 1537,
TA 98 and Escherichia coli WP2 uvrA (BASF 2006). Two independent assays
were performed, a standard plate test (SPT) and a preincubation test
(PIT), both with a dose range of 56 µg - 5500 µg/plate, and both with
and without metabolic activation (Aroclor 1254-induced rat liver S-9
An increase in the number of his+ or trp+
revertants was not observed in the standard plate test or in the
preincubation test either without S-9 mix or after the addition of a
metabolizing system. Precipitation of the test substance was found from
about 557 mg/plate onward. A slight decrease in the number of revertants
was occasionally observed depending on the strain and test conditions at
doses >= 1750 µg/plate.
According to the results of the present
study, the test substance is not mutagenic in the Salmonella
typhimurium/ Escherichia coli reverse mutation assay under the
experimental conditions chosen here.
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