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EC number: 470-080-3
CAS number: -
Individual weight of female animals (g)
In an acute oral toxicity study, groups of
fasted young Wistar rats (1 respectively 2 females) were given a single
oral dose of
in CMC-solution at a limit dose of 5000 mg/kg bw and observed for 14
Single doses of 5,000 mg/kg body weight of
test material preparations in 0.5% CMC-solution in doubly distilled
water were given to three fasted female animals (stepwise procedure
starting with one animal and supplementing two additional animals).
No mortality occurred. Clinical observation
revealed impaired general state, dyspnoea and piloerection . Findings
were observed from hour 1 until including hour 5 after administration.
The body weights increased throughout the study period. No macroscopic
pathologic abnormalities were noted in the animals examined at the end
of the observation period.
Under the conditions of this study the
median lethal dose of
after oral administration was found to be greater than 5000 mg/kg body
weight in rats .
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