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EC number: 470-080-3
CAS number: -
In an acute dermal toxicity study according
to OECD guideline 402, a single dose of 5000 mg/kg body weight of a test
material preparation (purity: 92.4 weight-%; dose volume 10 g/kg bw) in
0.5% CMC-solution in doubly distilled water was applied in five male and
five female animals to ca. 10% of the clipped skin (dorsal and
dorsolateral parts of the trunk) and covered by a semi-occlusive
dressing for 24 hours.
No mortality occurred. No systemic clinical
observations or skin effects were noted in the animals. The mean body
weights of the animals increased throughout the study period. No
macroscopic pathologic abnormalities were noted in the animals examined
at the end of the study.
Under the conditions of this study, the
acute dermal median lethal dose (LD50) of
after dermal application was found to be greater than 5000 mg/kg body
weight in male and female rats.
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