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EC number: 617-116-8
CAS number: 80573-04-2
A ready biodegradability study (OECD Guideline 310) showed that
balsalazide acid was not biodegradable under aerobic conditions.
Furthermore, it is predicted that balsalazide acid would hydrolyse very
slowly in the environment. Therefore, it is accepted that the half life
of balsalazide acid could exceed 60 days in water and 180 days in soil
and sediment and hence balsalazide acid is assigned a vP classification.
The partition coefficient of balsalazide acid was determined according
to OECD Guideline 117 and was found to be 1.00. Therefore, based on this
result, balsalazide acid is predicted not to bioaccumulate.
According to the ECHA Guidance on Information Requirements and Chemical
Safety Assessment Chapter R.11 (PBT/ vPvB assessment, version 3, 2017)
and following the annotated flow chart in the guidance (Figure R.11-5),
the T criterion is not fulfilled for balsalazide acid.
Since only the vP criterion is fulfilled, the overall conclusion of the
PBT assessment is that balsalazide acid is not considered to be a PBT or
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