Registration Dossier
Registration Dossier
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EC number: 930-930-0 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
Based on available data, it might be concluded that the substance is not a skin sensitizer. Thus, it is deemed that further studies on skin sensitization are not scientifically justified.
According to the EU Risk Assessment Report (2003), pg. 114-115, in spite of two reported cases of positive patch tests to hydrogen peroxide and the uncertainty surrounding an outdated animal study (with a negative result), and on recognition of the widespread occupational and consumer use over many decades, it may be confidently stated that the potential of hydrogen peroxide to cause skin sensitisation is extremely low and therefore do not meet the criteria for classification.
Moreover, there is no evidence of any sensitization potential for calcium compounds. Calcium is abundantly available in the environment, in food and extensively distributed throughout the human body. Sensitisation by or intolerance to an abundantly available essential element such as calcium would be grossly implausible and can therefore safely be excluded.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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