Registration Dossier
Registration Dossier
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EC number: 930-930-0 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No experimental data on toxicokinetics is available. Nevertheless, toxicokinetic information can be derived from the physicochemical properties and the chemical reactivity of the constituents of “reaction mass of calcium dihydroxide and calcium peroxide”.
The reaction mass can only be systemically available when it can be transported to different parts of the body after being dissolved in blood. Thus, the hydrolysis reaction of the reaction mass below can be taken into account in the assessment of toxicokinetics.
- CaO2 + 2 H2O -> Ca2 + + 2 OH- + H2O2
- H2O2 + H2O -> 2 H2O + O2
- Ca(OH)2 -> Ca2 + + 2 OH-
Therefore, the toxicity of the reaction mass is due to the hydrolysis product hydrogen peroxide (H2O2) and calcium dihydroxide (Ca(OH)2). The calcium dihydroxide that is both present in the reaction mass and formed upon hydrolysis of the calcium peroxide will mainly cause effects related to the pH change. Under physiological conditions, calcium hydroxide ultimately dissociates into calcium cations (Ca2 +) and hydroxyl anions (OH-). Calcium is an essential and abundantly available mineral nutrient. Hydroxyl anion is neutralized in body fluids and thus calcium hydroxide will only show the typical local effects associated with basic solutions. Furthermore,it is important to note that hydrogen peroxide is rapidly eliminated in the body as it is an endogenous metabolite and its concentration is normally kept in equilibrium. Its degradation takes place via the enzyme catalase and other detoxifying enzymespresent in blood and many tissues.
Consequently, the reaction mass is not expected to be systemically available since hydrogen peroxide is rapidly degraded in blood while calciumdihydroxid is neutralized due to the buffer capacity.
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