Registration Dossier
Registration Dossier
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EC number: 266-722-5 | CAS number: 67583-77-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Two acute fish studies exist for this test substance, the first an in vivo study following an ISO norm which featured certain drawbacks, notably the use of ultraturrax for 10 seconds to mix the test susbtance followed by immediate testing and the use of DOC rather than specific substance anslysis in order to determine test solution concentrations. Due to this it could not be confirmed that the maximum nominal concentration was attained or the true concentrations tested. Based on this information a calculation was used to transform DOC into equivalent test substance concentrations in order to improve the estimation of the LC50. Using the geometric mean of the 100% and 0% mortality concentrations, the 96 h LC50 result reduced from 172 mg/L based on nominal to 1.95 mg/L based on measured, transformed DOC values.
As this study was not considered strictly valid due to analytical limitations a QSAR model was also included. The test substance is within the applicability domain of this model and the QMRF and QPRF included in the RS. The 96 h LC50 was calculated at 1.7 mg/L, very close to the LC50 calculated from the in vivo fish study. On this basis, the results are considered accurate and the 96 LC50 of 1.7 mg/L will be used for C&L and risk assessment purposes.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.7 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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