Registration Dossier
Registration Dossier
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EC number: 266-722-5 | CAS number: 67583-77-1
Endpoint summary
Administrative data
Description of key information
Two acute fish studies exist for this test substance, the first anin vivostudy following an ISO norm which featured certain drawbacks. A calculation was needed to transform DOC into equivalent test substance concentrations in order to improve the estimation of the LC50. Using the geometric mean of the 100% and 0% mortality concentrations, the 96 h LC50 result was 1.95 mg/L based on measured, transformed DOC values. As this study was not considered strictly valid due to analytical limitations a QSAR model was also included. The 96 h LC50 was calculated at 1.7 mg/L, very close to the LC50 calculated from the in vivo fish study. On this basis, the results are considered accurate and the 96 LC50 of 1.7 mg/L is used for fish.
Two acute invertebrate studies exist for this test substance, the first a static,in vivostudy following OECD 202. The 48 h EC50 was 5.7 mg/L based on measured values.
The second study was a QSAR model, similar to that used for the fish study. The 48 h EC50 was calculated at 2.7 mg/L, close to the and slightly below the EC50 calculated from the in vivo daphnid study. On this basis, and considering that the substance appears to hydrolyse fairly rapidly (circa 50% within 48 hours) the results are considered accurate and the 48 h EC50 of 2.7 mg/L for invertebrates will be used for invertebrates.
Under the test conditions, the 72-hour ErC50 value was calculated to be 9.04 mg/L. The 72-hour NOErC was determined to be 0.476 mg/L. All concentrations refer to geometric mean measured concentrations.
The lowest value for aquatic species is 1.7 mg/L based on the 96 h LC50 for fish.
Additional information
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